PFAS are widely used in materials such as PTFE. PTFE is commonly used in chemical analysis consumables. Laboratories require labware products that do not contain PTFE to minimize background contamination. The analytical detection method of choice for PFAS analysis is liquid chromatography - mass spectrometry – mass spectrometry (LC/MS/MS), which is especially suited for analysis of ionic compounds such as the PFSAs and PFCAs. Gas chromatography-mass spectrometry (GC/MS) can also be used for PFAS analysis. However, while LC/MS/MS analysis of PFAS is widely available, GC/MS analysis has limited commercial availability for PFAS. While most analytical methods used for PFAS utilize LC/MS/MS, just as with sample preparation, there are significant ways in which the method differ that need to be considered when selecting a method
